The major public school district in Plano is the Plano Independent School District, which has 53,000 students and 6,500 faculty members in 65 schools and 3 special and early education centers. Other parts of Plano are served by the Lewisville Independent School District, the Frisco Independent School District, and the Allen Independent School District.

There are also two campuses of the Collin County Community College District that are located in Plano.